Metabolic Disorders and the Nervous System

Diagnosis of inherited metabolic disorders affecting the nervous system.

Knowledge of the molecular causes for genetic diseases that affect the nervous system is rapidly expanding. Especially striking has been the finding in several autosomal dominant neurodegenerative disorders that unstable expansions of trinucleotide repeats are responsible for the genetic disorder and that the length of the repeat can be correlated with the age of onset and the severity of sympt...

O 14: Differentiating Demyelinating Disorders of the Central Nervous System – a Focus on Multiple Sclerosis and Neuromyelitis-Optica Spectrum Disorders

Significant advances have been made in diagnosis and therapy of demyelinating disorders of the central nervous system. The most common entities of this disorders in adults – multiple sclerosis and neuromyelitis optica were initially thought to be different phenotypes of more or less the same disease. During the last ten years, this view was subsequently changed and the term neuromyelitis ...

HCV-Related Nervous System Disorders

Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immun...

Disorders of the autonomic nervous system.

FURTHER READINGS Bosco D et al: Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci, 11:1396, 2010 Bruijn LI, Cudkowicz M: Therapeutic targets for amyotrophic lateral sclerosis: Current treatments and prospects for more effective therapies. Expert Rev Neurother 6:417, 2006 Digiorgio et al: Non-cell autonomous effect of glia on motor neur...

Nutritional Disorders of the Nervous System